Ntlha ea pele e amang ho boloka metsi kaHydroxypropyl methylcellulose(HPMC)lihlahisoa ke tekanyo ea ho fetola (DS). DS e bolela palo ea lihlopha tsa hydroxypropyl le methyl tse khomaretsoeng yuniti e 'ngoe le e 'ngoe ea selulose. Ka kakaretso, ha DS e phahame, e ntlafatsa boleng ba ho boloka metsi ba HPMC. Lebaka ke hore DS e eketsehileng e lebisa ho lihlopha tse ngata tsa hydrophilic mokokotlong oa cellulose, e leng se lumellang tšebelisano e matla le limolek'hule tsa metsi le matla a matla a ho tšoara metsi.
Ntho e 'ngoe ea bohlokoa e susumetsang ho boloka metsi ke boima ba limolek'hule tsa HPMC. Boima ba limolek'hule bo ama viscosity ea tharollo ea HPMC, 'me li-polymers tse phahameng tsa boima ba limolek'hule hangata li bonts'a thepa e ntle ea ho boloka metsi. Boholo bo boholo ba li-polymer tsena bo etsa hore ho be le marang-rang a mangata, ho eketsa ho kenngoa ha limolek'hule tsa metsi 'me ka lebaka leo ho ntlafatsa ho boloka metsi. Leha ho le joalo, ke habohlokoa ho fumana tekanyo, kaha boima bo feteletseng ba limolek'hule bo ka fella ka ho eketseha ha viscosity le ho fokotseha ha mosebetsi, ho etsa hore ho be thata ho sebetsana kapa ho sebelisa lihlahisoa tsa HPMC lits'ebetsong tse itseng.
Ho feta moo, khatello ea maikutlo ea HPMC ka har'a motsoako le eona e phetha karolo ea bohlokoa ho bolokeng metsi. Maemo a phahameng a HPMC hangata a lebisa mekhoeng e betere ea ho boloka metsi. Sena se bakoa ke hore khatello e phahameng e eketsa palo ea libaka tsa hydrophilic tse fumanehang bakeng sa ho monya metsi, e leng se etsang hore ho be le matla a ho boloka metsi. Leha ho le joalo, ho tsepamisa mohopolo ho feteletseng ho ka lebisa ho ho eketseha ha viscosity, ho etsa hore sebopeho se be thata ho sebetsana le ho se sebelisa. Ho bohlokoa ho fumana khokahanyo e nepahetseng ea HPMC e ipapisitseng le ts'ebeliso e ikhethileng ea ho fihlela thepa e lakatsehang ea ho boloka metsi ntle le ho senya ts'ebetso ea sehlahisoa.
Ho phaella ho lintlha tsena tse ka sehloohong, lintlha tse ling tse sa tšoaneng li ka susumetsa thepa ea ho boloka metsi eaHPMClihlahisoa. Mofuta le palo ea li-additives tse sebelisoang ha ho etsoa li ka ba le phello e kholo. Mohlala, tlatsetso ea li-plasticizers kapa rheology modifiers e ka ntlafatsa ho bolokoa ha metsi ka ho fetola sebopeho sa HPMC le ho sebelisana le limolek'hule tsa metsi. Mabaka a tikoloho a kang mocheso le mongobo le ona a ka ama ho bolokoa ha metsi, kaha mekhahlelo ena e susumetsa sekhahla sa mouoane oa metsi le ho monyeha ha metsi. Thepa ea substrate kapa bokaholimo bo ka ama ts'ebetso ea metsi ho feta, kaha phapang ea porosity kapa hydrophilicity e ka ama bokhoni ba substrate ho monya le ho boloka metsi.
Thepa ea ho boloka metsi ea lihlahisoa tsa HPMC e susumetsoa ke lintlha tse fapaneng, ho kenyeletsoa tekanyo ea phetoho, boima ba limolek'hule, mahloriso, li-additives, lintlha tsa tikoloho le thepa ea substrate. Ho bohlokoa ho utloisisa lintlha tsena ha ho etsoa moraloLihlahisoa tse thehiloeng ho HPMCbakeng sa lisebelisoa tse fapaneng. Ka ho ntlafatsa lintlha tsena, bahlahisi ba ka ntlafatsa thepa ea ho boloka metsi ea HPMC le ho netefatsa katleho ea eona liindastering tse kang tsa meriana, kaho le tlhokomelo ea motho ka mong. Liphuputso tse ling le nts'etsopele lefapheng lena li tla tsoelapele ho atolosa kutloisiso ea rona ea lintlha tse susumetsang ho bolokoa ha metsi lihlahisoa tsa HPMC le ho etsa hore ho be le mekhoa e metle le e sebetsang haholoanyane.
Nako ea poso: Nov-02-2023